AH 6809

CAT: 0804-HY-10418-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-10418-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor[1][2][3].

CAS Number

33458-93-4

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AH-6809.html

Purity

99.57

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1C2=C(C=CC(C(O)=O)=C2)OC3=CC(OC(C)C)=CC=C31

Molecular Formula

C17H14O5

Molecular Weight

298.29

Precautions

H315, H319, H335

References & Citations

[1]Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483 (2) :285-93.|[2]Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122 (2) :217-24.|[3]Woodward DF, et, al. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol. 1995 Nov 9;50 (10) :1731-3.|[4]Zoccal KF, et, al. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun. 2016 Feb 23;7:10760.|[5]Keery RJ, et, al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94 (3) :745-54.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

DP; EP

Related Products

Catalog	Name
HY-129661-01	AH 7959
HY-121048	AH 7725
HY-W714509-01	AH 8507
HY-W325509-01	AH 8532
HY-W714505-01	AH 7563
HY-116500A	AH-1058
HY-19996-01	AH-7614
HY-131930-01	AH-8533
HY-101345-01	AH 11110A
HY-W326260-01	AH 8529

Alternative Products

Catalog	Name
T14148-01	AH 6809
BML-RA110-0005	AH-6809
T30842-01	Cgp 6809

AH 6809

Related Products

Alternative Products

Popular Products