8-Chloroadenosine (Standard)

• Description:

  8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].

• Product Name Alternative:

  8-Cl-Ado (Standard)

• UNSPSC:

  12352005

• Target:

  AMPK; Autophagy; Nucleoside Antimetabolite/Analog; Reference Standards

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO

• Molecular Formula:

  C10H12ClN5O4

• Molecular Weight:

  301.69

• References & Citations:

  [1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [34408-14-5]