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8-Chloroadenosine (Standard)

CAT: 0804-HY-103400RSize: 1 EachDry Ice: NoHazardous: No
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Description
8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].
CAS Number
34408-14-5
Product Name Alternative
8-Cl-Ado (Standard)
UNSPSC
12352005
Target
AMPK; Autophagy; Nucleoside Antimetabolite/Analog; Reference Standards
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
Molecular Formula
C10H12ClN5O4
Molecular Weight
301.69
References & Citations
[1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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