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(R) -Niguldipine

CAT: 0804-HY-101390DSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101390DSize:1 Each
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Description
(R) -Niguldipine, a R-epimer of Niguldipine , is a calcium channel antagonist. (R) -Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R) -Niguldipine can inhibit U-46619 (HY-108566) -induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (R) -Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias[1].
CAS Number
120054-86-6
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@H]1C2=CC([N+]([O-])=O)=CC=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3
Molecular Formula
C36H39N3O6
Molecular Weight
609.71
References & Citations
[1]Eltze M, et al. Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists. Chirality. 1990;2 (4) :233-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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