8-M-PDOT (Standard)

• Description:

  8-M-PDOT (Standard) is the analytical standard of 8-M-PDOT (HY-101358) . This product is intended for research and analytical applications. 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

• Target:

  Melatonin Receptor; Reference Standards

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research:

  Neurological Disease

• Smiles:

  CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

• Molecular Formula:

  C14H19NO2

• Molecular Weight:

  233.31

• References & Citations:

  [1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000 Mar;129 (5) :877-86.|[2]Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9 (1) :47-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  134865-70-6