8-M-PDOT

• Description:

  8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

• Product Name Alternative:

  AH-002

• UNSPSC:

  12352005

• Target:

  Melatonin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/8-m-pdot.html

• Purity:

  99.33

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

• Molecular Formula:

  C14H19NO2

• Molecular Weight:

  233.31

• References & Citations:

  [1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000 Mar;129 (5) :877-86.|[2]Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9 (1) :47-54.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MT2

• CAS Number:

  [134865-70-6]