8-M-PDOT

• Description :

  8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

• Product Name Alternative :

  AH-002

• UNSPSC :

  12352005

• Target :

  Melatonin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/8-m-pdot.html

• Purity :

  99.33

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

• Molecular Formula :

  C14H19NO2

• Molecular Weight :

  233.31

• References & Citations :

  [1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000 Mar;129 (5) :877-86.|[2]Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9 (1) :47-54.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MT2

• CAS Number :

  [134865-70-6]