PI-103 (Standard)

• Description:

  PI-103 (Standard) is the analytical standard of PI-103. This product is intended for research and analytical applications. PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with an IC50 of 2 nM. PI-103 induces autophagy[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; DNA-PK; mTOR; PI3K; Reference Standards

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)OC5=C3C=CC=N5)=CC=C1

• Molecular Formula:

  C19H16N4O3

• Molecular Weight:

  348.36

• References & Citations:

  [1]Raynaud FI, et al. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103through PI-540, PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 2009 Jul;8 (7) :1725-39.|[2]Park S, et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase anLeukemia. 2008 Sep;22 (9) :1698-706.d mTOR, has antileukemicactivity in AmL. Leukemia. 2008 Sep;22 (9) :1698-706.|[3]López-Fauqued M, et al. The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of melanoma cells. Int J Cancer. 2010 Apr 1;126 (7) :1549-61.|[4]Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110 alpha. Cell. 2006 May 19;125 (4) :733-47.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [371935-74-9]