MBM-55 (Standard)

• Description:

  MBM-55 (Standard) is the analytical standard of MBM-55 (HY-101029) . This product is intended for research and analytical applications. MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM) . MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].

• Target:

  Apoptosis; NEKs; Reference Standards

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Others

• Field of Research:

  Cancer

• Smiles:

  NC (C (C=C1) =C (OCC2=CC=CC (F) =C2) C=C1C3=CN=C4N3C=CC (C5=CN (CCN (C) C) N=C5) =C4) =O

• Molecular Formula:

  C28H27FN6O2

• Molecular Weight:

  498.55

• References & Citations:

  [1]Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  2083622-09-5