RegisterLogin

MBM-17S

CAT: 0804-HY-101030ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101030ASize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MBM-17S is a potent NIMA-related kinase 2 (Nek2) inhibitor, with an IC50 of 3 nM. MBM-17S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-17S shows antitumor activities, and no obvious toxicity to mice[1].
CAS Number
[2083621-91-2]
UNSPSC
12352005
Target
Apoptosis; NEKs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mbm-17s.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC(O)=O.O=C(O)CCC(O)=O.NC(C(C=C1)=C(OCC2=CC=CC=C2)C=C1C3=CN=C4N3C=CC(C5=CN(CCN(C)C)N=C5)=C4)=O
Molecular Formula
C36H40N6O10
Molecular Weight
716.74
References & Citations
[1]Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK2

Related Products

CatalogName
HY-101029AMBM-55S
HY-101029-01MBM-55
HY-101030MBM-17
HY-101029RMBM-55 (Standard)
HY-155286(7S,8R,17S) -RCTR1
HY-113040(17S,18R) -Epoxyeicosatetraenoic acid
HY-114461B(3S,17S) -FD-895
HY-Z8245R(8S,9S,10R,13S,14S,17S) -17- ((R) -1-Hydroxyethyl) -10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3 (2H) -one (Progesterone Impurity) (Standard)
HY-Z6678R(S) -1- ((8S,9S,10R,13S,14S,17S) -10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl) ethyl acetate (Progesterone Impurity) (Standard)
HY-Z8246R(R) -1- ((8S,9S,10R,13S,14S,17S) -10,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl) ethyl acetate (Progesterone Impurity) (Standard)

Alternative Products

CatalogName
T11959-01MBM-17S
MBS387262-01MBM-55
T11961-01MBM-55S
MBS387255-01MBM-17
A12499-10MBM-17 10mg
A12510-5MBM-55 5mg
A12510-100MBM-55 100mg
A12510-500MBM-55 500mg
TRC-V754800-25MG(17S)-Volicitin
A12499-1MBM-17 1mg

Popular Products