FG 7142 (Standard)

• Description :

  FG 7142 (Standard) is the analytical standard of FG 7142. This product is intended for research and analytical applications. FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM) . FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM) . FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of?β-adrenoceptors in mouse cerebral cortex[1].

• Product Name Alternative :

  ZK 39106 (Standard) ; LSU-65 (Standard)

• UNSPSC :

  12352005

• Target :

  GABA Receptor; Reference Standards

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC

• Molecular Formula :

  C13H11N3O

• Molecular Weight :

  225.25

• References & Citations :

  [1]Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32 (5) :1069-81. Epub 2006 Nov 1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [78538-74-6]