FG 7142 (Standard)

CAT: 0804-HY-100991RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100991RSize:1 Each
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Description
FG 7142 (Standard) is the analytical standard of FG 7142. This product is intended for research and analytical applications. FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM) . FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM) . FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of?β-adrenoceptors in mouse cerebral cortex[1].
CAS Number
[78538-74-6]
Product Name Alternative
ZK 39106 (Standard) ; LSU-65 (Standard)
UNSPSC
12352005
Target
GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC
Molecular Formula
C13H11N3O
Molecular Weight
225.25
References & Citations
[1]Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32 (5) :1069-81. Epub 2006 Nov 1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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