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FG 7142

CAT: 0804-HY-100991-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100991-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM) . FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM) . FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1].
CAS Number
78538-74-6
Product Name Alternative
ZK 39106; LSU-65
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fg-7142.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC
Molecular Formula
C13H11N3O
Molecular Weight
225.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32 (5) :1069-81. Epub 2006 Nov 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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