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Sulodexide solution

CAT: 0804-HY-100897A-01Size: 200 µLDry Ice: NoHazardous: No
CAT#:0804-HY-100897A-01Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulodexide solution is a mixture of glycosaminoglycans that can be administered by injection. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%) . Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA) . Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.
CAS Number
[57821-29-1]
UNSPSC
12352211
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
[Sulodexidesolution]
References & Citations
[1]Andreozzi GM. Sulodexide in the treatment of chronic venous disease. Am J Cardiovasc Drugs. 2012 Apr 1;12 (2) :73-81. |[2]Yung S, et al. Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy[J]. PloS one, 2013, 8 (1) : e54501.|[3]Jo H, et al. Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy[J]. BMB reports, 2014, 47 (11) : 637.|[4]Huang R, et al. Sulodexide attenuates liver fibrosis in mice by restoration of differentiated liver sinusoidal endothelial cell[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114396.|[5]Ying J, et al. Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis[J]. Frontiers in immunology, 2023, 14: 1172892.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C, do not freeze
Scientific Category
Reference compound1
Clinical Information
Phase 4

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