Natalizumab (Solution)

CAT: 0804-HY-108831A-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0804-HY-108831A-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Natalizumab (Solution) (AN100226; BG00002) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1) . Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses[1].

CAS Number

189261-10-7

Product Name Alternative

AN100226; BG00002

UNSPSC

12352203

Target

Integrin

Type

Inhibitory Antibodies

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/natalizumab-solution.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

[Natalizumab(Solution)]

Molecular Weight

(146.22 kDa)

References & Citations

[1]Hutchinson M. Natalizumab: A new treatment for relapsing remitting multiple sclerosis. Ther Clin Risk Manag. 2007 Jun;3 (2) :259-68.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 4

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Natalizumab (Solution)

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