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CGS 15943 (Standard)

CAT: 0804-HY-100678RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100678RSize:1 Each
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Description
CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [1][2].
CAS Number
104615-18-1
UNSPSC
12352005
Target
Adenosine Receptor; PI3K; Reference Standards
Related Pathways
GPCR/G Protein; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Inflammation/Immunology
Smiles
NC1=NC2=C(C=C(Cl)C=C2)C3=NC(C4=CC=CO4)=NN13
Molecular Formula
C13H8ClN5O
Molecular Weight
285.69
References & Citations
[1]Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55 (3) :PL61-5.|[2]Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362 (4-5) :382-91.|[3]Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15 (5) :524-32.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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