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FCCP (Standard)

CAT: 0804-HY-100410R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100410R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].
CAS Number
370-86-5
Product Name Alternative
Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (Standard)
UNSPSC
12352005
Target
Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin; Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Cancer
Smiles
N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
Molecular Formula
C10H5F3N4O
Molecular Weight
254.17
References & Citations
[1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p- (trifluoromethoxy) phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72 (4) :1457-65.|[2]Tanpradit N, et al. Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33 (12) :1621-1631. Epub 2016 Sep 17.|[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2 (5) :120080.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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