FCCP

• UNSPSC Description:

  FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

• Target Antigen:

  Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/FCCP.html

• Purity:

  99.30

• Solubility:

  DMSO : ≥ 100 mg/mL|Ethanol : ≥ 33.3 mg/mL

• Smiles:

  N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1

• Molecular Weight:

  254.17

• References & Citations:

  [1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.|[2]Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17.|[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  370-86-5