E 2012 (Standard)

CAT: 0804-HY-10016RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-10016RSize:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E 2012 (Standard) is the analytical standard of E 2012 (HY-10016) . This product is intended for research and analytical applications. E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat[1].
CAS Number
[870843-42-8]
Target
Reference Standards; γ-secretase
Related Pathways
Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(N([C@H](C1=CC=C(C=C1)F)C)CCC/2)C2=C\C3=CC=C(N4C=NC(C)=C4)C(OC)=C3
Molecular Formula
C25H26FN3O2
Molecular Weight
419.49
References & Citations
[1]Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137 (1) :249-58.|[2]Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K.Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.J Alzheimers Dis. 2010;21 (3) :1005-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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