E 2012

CAT: 0931-MF-0018010-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0018010-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
870843-42-8
Target
Gamma-secretase
Related Pathways
Stem Cells|||Proteases/Proteasome|||Neuroscience
Purity
0.9983
Bioactivity
E2012 is a ?-secretase modulator (GSM) . E2012 inhibits 3?-hydroxysterol ?24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid ?-42, and induces cataract following repeated doses in the rat.
Smiles
COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1
Molecular Formula
C25H26FN3O2
Molecular Weight
419.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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