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Rabbit Polyclonal Antibody to SRGAP3

CAT: 1725-P08804-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P08804-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Product Name Alternative
WRP; MEGAP; SRGAP2; ARHGAP14
Swiss Prot
O43295
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Fusion protein of human SRGAP3
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
SRGAP3

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