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(Rac) -EBET-1055

CAT: 0931-TYD-04106-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-04106-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3031540-65-2
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
(R, R) -VRT-534 is the enantiomer of VRT-534. EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader. It effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC) . Additionally, EBET-1055 modulates cancer-associated fibroblast (CAF) activity, increasing the activity of all reporter genes in organoid co-cultures.
Smiles
O=C1C=2C=CC=C(OCC(=O)N3CCN(CC3)CC4CCN(C=5N=C6C=CC(=CC6=C(N5)C(OC7CC7)(C=8C=CC=CC8)CO)C=9C=C(C(=O)N(C9)C)C)CC4)C2C(=O)N1C%10C(=O)NC(=O)CC%10
Molecular Formula
C51H54N8O9
Molecular Weight
923.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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