Bis-sulfone-PEG4-NHS ester

CAT: 0931-TYD-02035-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TYD-02035-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2055047-19-1

Bioactivity

Bis-sulfone-PEG4-NHS ester is a bifunctional alkylating labeling reagent that selectively removes cysteine sulfur atoms from native disulfide bonds. These reagents perform bis-alkylation to attach both thiols from two cysteine residues, originating from reduced native disulfide bonds (such as interchain disulfide bonds in antibodies) . The reaction results in a covalent bond through a three-carbon bridge, maintaining the protein's structural integrity. The hydrophilic PEG spacer enhances its solubility in aqueous media.

Smiles

O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C(=O)C(CS(=O)(=O)C3=CC=C(C=C3)C)CS(=O)(=O)C4=CC=C(C=C4)C

Molecular Formula

C40H48N2O14S2

Molecular Weight

844.944

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Bis-sulfone-PEG4-NHS ester

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