RP-220

• CAS Number :

  1541177-35-8

• Target :

  P38 MAPK|||Apoptosis|||NOD-like Receptor (NLR)

• Related Pathways :

  MAPK|||Apoptosis|||Immunology/Inflammation

• Bioactivity :

  RP-220 is a peptide that targets the NLRP3 enzyme and exhibits anti-inflammatory and anti-apoptotic properties. It inhibits apoptosis of renal tubular epithelial cells caused by alkaline damage by activating the MAPK signaling pathway. In mouse models of acute kidney injury (AKI), RP-220 significantly reduces NLRP3 expression, macrophage infiltration, and renal tissue damage. Additionally, RP-220 is applicable in research on systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) .

• Smiles :

  [C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CO)=O)CO)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)CO)=O)C(C)C)=O

• Molecular Formula :

  C98H166N30O32S

• Molecular Weight :

  2308.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C