RP-220

• Target:

  P38 MAPK|||Apoptosis|||NOD-like Receptor (NLR)

• Related Pathways:

  MAPK|||Apoptosis|||Immunology/Inflammation

• Bioactivity:

  RP-220 is a peptide that targets the NLRP3 enzyme and exhibits anti-inflammatory and anti-apoptotic properties. It inhibits apoptosis of renal tubular epithelial cells caused by alkaline damage by activating the MAPK signaling pathway. In mouse models of acute kidney injury (AKI), RP-220 significantly reduces NLRP3 expression, macrophage infiltration, and renal tissue damage. Additionally, RP-220 is applicable in research on systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) .

• Smiles:

  [C@@H] (CC1=CC=CC=C1) (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CS) N) =O) [C@H] (CC) C) =O) CCCNC (=N) N) =O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (NCC (O) =O) =O) [C@H] (CC) C) =O) CCC (O) =O) =O) CO) =O) CO) =O) CCC (O) =O) =O) [C@H] (CC) C) =O) CC (N) =O) =O) CCCNC (=N) N) =O) CCCCN) =O) CCCCN) =O) CC (N) =O) =O) CC (O) =O) =O) [C@H] (CC) C) =O) CO) =O) C (C) C) =O

• Molecular Formula:

  C98H166N30O32S

• Molecular Weight:

  2308.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1541177-35-8