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RP-220

CAT: 0931-TP3871-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3871-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1541177-35-8
Target
P38 MAPK, Apoptosis, NOD-like Receptor (NLR)
Related Pathways
MAPK, Apoptosis, Immunology/Inflammation
Bioactivity
RP-220 is a peptide that targets the NLRP3 enzyme and exhibits anti-inflammatory and anti-apoptotic properties. It inhibits apoptosis of renal tubular epithelial cells caused by alkaline damage by activating the MAPK signaling pathway. In mouse models of acute kidney injury (AKI), RP-220 significantly reduces NLRP3 expression, macrophage infiltration, and renal tissue damage. Additionally, RP-220 is applicable in research on systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) .
Smiles
[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CO)=O)CO)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)CO)=O)C(C)C)=O
Molecular Formula
C98H166N30O32S
Molecular Weight
2308.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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