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LVTX-8

CAT: 0931-TP3758-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3758-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2197957-07-4
Target
Apoptosis, MDM-2/p53, Integrin
Related Pathways
Apoptosis, Cytoskeletal Signaling
Bioactivity
LVTX-8 is a peptide toxin extracted from Lycosa vittata. It exhibits potent anticancer and antimetastatic effects against lung cancer, with strong cytotoxicity. LVTX-8 significantly induces apoptosis via the P53 hypoxia pathway and integrin signaling, inhibiting proliferation, invasion, and migration of lung cancer cells. It markedly suppresses tumor growth and metastasis in A549/H460 xenograft mouse models.
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)C)=O)CC(C)C)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CC(N)=O)=O)CCCCN)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CC(C)C)=O)NC([C@H]([C@H](CC)C)N)=O)C=3C=4C(NC3)=CC=CC4
Molecular Formula
C135H226N36O31
Molecular Weight
2849.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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