Ac-DMLD-CMK

CAT: 0931-TP3236-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TP3236-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2588354-33-8

Target

Caspase, Pyroptosis

Related Pathways

Proteases/Proteasome, Immunology/Inflammation, Apoptosis

Bioactivity

Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.

Smiles

[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)(NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CCSC)=O)CC(C)C

Molecular Formula

C22H35ClN4O9S

Molecular Weight

567.053

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Ac-DMLD-CMK

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