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ETTAC-2

CAT: 0931-TP3119-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3119-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TGF-beta/Smad, PROTACs
Related Pathways
PROTAC, Stem Cells
Bioactivity
ETTAC-2 is an LRG1 PROTAC degrader that facilitates the ubiquitination and degradation of LRG1, with a DC50 of 8.38 μM. It inhibits the TGF-β-Smad3 signaling pathway and reduces the secretion of proteins associated with fibrosis. ETTAC-2 can slow the progression of renal fibrosis.
Smiles
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)CNC(=O)CCC(=O)NC3=CC=CC4=C3CN(C4=O)C5CCC(=O)NC5=O
Molecular Formula
C83H123N23O26S
Molecular Weight
1891.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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