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BMP-4

CAT: 0931-TP2930-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2930-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1629625-47-3
Target
COX, Interleukin, IFNAR
Related Pathways
Neuroscience, Immunology/Inflammation
Bioactivity
BMP-4, a heparin-binding peptide, exhibits anti-inflammatory and anti-chondrogenic properties. In murine chondrocytes and macrophages, it effectively mitigates inflammation and alleviates symptoms of various arthritides by dose-dependently suppressing the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 through modulation of the iNOS-IFN-IL6 signaling pathway.
Smiles
C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CS)=O)CC(N)=O)(=O)[C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)CCC2
Molecular Formula
C52H93N25O13S
Molecular Weight
1308.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

H-Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His-OH
CAS Number1629625-47-3
PubChem CID172638715
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-3-sulfanylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
Molecular FormulaC52H93N25O13S
Molecular Weight1308.5
XLogP-12.4
Topological Polar Surface Area678
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count21
Rotatable Bond Count45
Heavy Atom Count91
Formal Charge0
Complexity2540
SMILES
C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CN=CN2)C(=O)O
InChI
InChI=1S/C52H93N25O13S/c53-15-3-1-10-29(69-40(80)28(55)9-5-17-65-50(58)59)41(81)70-30(11-2-4-16-54)43(83)74-34(23-39(57)79)48(88)77-20-8-14-37(77)47(87)73-33(22-38(56)78)45(85)76-36(25-91)46(86)72-31(12-6-18-66-51(60)61)42(82)71-32(13-7-19-67-52(62)63)44(84)75-35(49(89)90)21-27-24-64-26-68-27/h24,26,28-37,91H,1-23,25,53-55H2,(H2,56,78)(H2,57,79)(H,64,68)(H,69,80)(H,70,81)(H,71,82)(H,72,86)(H,73,87)(H,74,83)(H,75,84)(H,76,85)(H,89,90)(H4,58,59,65)(H4,60,61,66)(H4,62,63,67)/t28-,29-,30-,31-,32-,33-,34-,35-,36-,37-/m0/s1
InChIKey
CAJMJFZJBYJDGF-ZHTQEPFFSA-N
Chemical Structure
2D Structure
2D structure of H-Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His-OH
CAS: 1629625-47-3
CID: 172638715
Formula: C52H93N25O13S
MW: 1308.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1308.5
XLogP3-12.4
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count21
Rotatable Bond Count45
Exact Mass1307.71053930
Monoisotopic Mass1307.71053930
Topological Polar Surface Area678 Ų
Heavy Atom Count91
Formal Charge0
Complexity2540
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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167766-01BMP-4, Recombinant, Human, aa1-116 (human BMP-4, BMP-4, BMP4, BMP 4, h-BMP-4, rh-BMP-4, recombinant human BMP-4, recombinant BMP-4, BMP) discontinued
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