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MO-2097

CAT: 0931-TN11446-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-TN11446-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2744300-63-6
Target
ROS, Apoptosis, Caspase, MEK, ERK, HIF/HIF Prolyl-Hydroxylase, Raf
Related Pathways
Immunology/Inflammation, Metabolism, Apoptosis, Proteases/Proteasome, Chromatin/Epigenetic, MAPK
Bioactivity
MO-2097 is an inhibitor of RAF-1 and HIF-1α. It destabilizes RAF-1, reducing EMT-related transcription factors and mesenchymal markers. MO-2097 suppresses HIF-1α protein expression under hypoxic or hypoxia-mimicking conditions via hnRNPA2B1. It induces mitochondrial ROS production, leading to cell apoptosis. By inhibiting the RAF/MEK/ERK signaling pathway, MO-2097 effectively prevents colorectal cancer metastasis. It also inhibits tumor growth in human colorectal cancer HCT116 cell xenograft mouse models. MO-2097 is applicable for colorectal cancer research.
Smiles
OC=1C=C(O)C=C(C1)C=2OC=3C=C4OCC(=CCC4=CC3C2)C
Molecular Formula
C19H16O4
Molecular Weight
308.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

5-(7-Methyl-5,8-dihydrofuro[3,2-h][1]benzoxepin-2-yl)benzene-1,3-diol
CAS Number2744300-63-6
PubChem CID176297910
IUPAC Name5-(7-methyl-5,8-dihydrofuro[3,2-h][1]benzoxepin-2-yl)benzene-1,3-diol
Molecular FormulaC19H16O4
Molecular Weight308.3
XLogP3.8
Topological Polar Surface Area62.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count23
Formal Charge0
Complexity452
SMILES
CC1=CCC2=C(C=C3C(=C2)C=C(O3)C4=CC(=CC(=C4)O)O)OC1
InChI
InChI=1S/C19H16O4/c1-11-2-3-12-4-13-7-18(14-5-15(20)8-16(21)6-14)23-19(13)9-17(12)22-10-11/h2,4-9,20-21H,3,10H2,1H3
InChIKey
FNKVYUANMNGOPU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(7-Methyl-5,8-dihydrofuro[3,2-h][1]benzoxepin-2-yl)benzene-1,3-diol
CAS: 2744300-63-6
CID: 176297910
Formula: C19H16O4
MW: 308.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass308.10485899
Monoisotopic Mass308.10485899
Topological Polar Surface Area62.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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