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ATZ-1993

CAT: 0804-HY-122237Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122237Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].
CAS Number
219705-77-8
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atz-1993.html
Smiles
O=C(C1=NN(C(C2=CC=CC(OCC)=C2)CC)C3=C1CCC4=CC(OCC5=CN=CN=C5)=CC=C43)O
Molecular Formula
C28H28N4O4
Molecular Weight
484.55
References & Citations
[1]Azuma H, et al. ATZ1993, an orally active and novel nonpeptide antagonist for endothelin receptors and inhibition of intimal hyperplasia after balloon denudation of the rabbit carotid artery. Jpn J Pharmacol. 1999 Sep;81 (1) :21-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA; ETB

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