Anticancer agent 249

• Target:

  Apoptosis|||HSP

• Related Pathways:

  Apoptosis|||Cytoskeletal Signaling|||Metabolism

• Bioactivity:

  Anticanceragent 249 (Compound 89) is an inhibitor of Hsp90?, exhibiting an IC50 of 16.5 ?M in PC3MM2 cells. It suppresses the proliferation of various cancer cell lines including MCF-7, T47D, MDA-MB-231, MDA-MB-468, and SKBr3, with IC50 values ranging from 1.8 to 5.3 ?M. Additionally, Anticanceragent 249 induces apoptosis in MDA-MB-231 cells and demonstrates antitumor activity in mice.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C