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AZ 5704

CAT: 0931-T35942-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T35942-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1941214-06-7
Target
Others|||ATM/ATR
Related Pathways
PI3K/Akt/mTOR signaling|||Others|||DNA Damage/DNA Repair
Bioactivity
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay) . Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 ?M) . Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.
Smiles
N([C@@H](C)C1=NN(C)C=C1)C=2C3=C(C=C(F)C(=C3)C=4C=CC(COC)=NC4)N=CC2C(N)=O
Molecular Formula
C23H23FN6O2
Molecular Weight
434.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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