AZ 5704

• Target:

  Others|||ATM/ATR

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Others|||DNA Damage/DNA Repair

• Bioactivity:

  Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay) . Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 ?M) . Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.

• Smiles:

  N([C@@H](C)C1=NN(C)C=C1)C=2C3=C(C=C(F)C(=C3)C=4C=CC(COC)=NC4)N=CC2C(N)=O

• Molecular Formula:

  C23H23FN6O2

• Molecular Weight:

  434.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1941214-06-7