TYRA-300

• Target:

  FGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity:

  0.9966

• Bioactivity:

  TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.

• Smiles:

  S(C)(=O)(=O)N1CC2(CN(C2)C3=CC=C(C=N3)C=4C=5C(NN4)=CC=C(O[C@H](C)C=6C(Cl)=CN=CC6Cl)C5)C1

• Molecular Formula:

  C25H24Cl2N6O3S

• Molecular Weight:

  559.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2800223-30-5