TYRA-300

CAT: 0931-MF-0095519-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0095519-01Size:1 mg
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CAS Number
2800223-30-5
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.9966
Bioactivity
TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.
Smiles
S(C)(=O)(=O)N1CC2(CN(C2)C3=CC=C(C=N3)C=4C=5C(NN4)=CC=C(O[C@H](C)C=6C(Cl)=CN=CC6Cl)C5)C1
Molecular Formula
C25H24Cl2N6O3S
Molecular Weight
559.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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