TRPC antagonist 1

• Target:

  TRP/TRPV Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  TRPC antagonist1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50 values of 2.4 ?M, 12.2 ?M, 7.6 ?M, 2.9 ?M, and 3.4 ?M for TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, respectively. It demonstrates significant anti-glioblastoma efficacy in vitro against the U87 cell line.

• Smiles:

  O=C(NC1=CC=C(O)C=C1)C=2N=C(SC2)N(CC=3C=CC=4C=CC=CC4C3)CCN

• Molecular Formula:

  C23H22N4O2S

• Molecular Weight:

  418.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3027139-12-1