Anticancer agent 235

CAT: 0931-MF-0148130-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0148130-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411108-21-7
Target
Reactive Oxygen Species|||Akt|||Apoptosis|||PI3K
Related Pathways
PI3K/Akt/mTOR signaling|||Metabolism|||Cytoskeletal Signaling|||Immunology/Inflammation|||Apoptosis|||NF-?B
Bioactivity
Anticanceragent 235 (Compound 49) functions as a modulator of the PI3K/AKT/mTOR signaling pathway, enhancing reactive oxygen species (ROS) production and reducing mitochondrial membrane potential, thereby inhibiting the proliferation of cancer cell lines HCT116, Caco-2, AGS, and SMMC-772 with IC50 values ranging from 0.35 to 26.9 ?M. Additionally, it induces apoptosis and causes cell cycle arrest at the G2/M phase in HCT-116 cells.
Smiles
ClC1=CC=C2C(=C1)C=C3C(=NC=4C=C(OC)C=CC43)N2C
Molecular Formula
C17H13ClN2O
Molecular Weight
296.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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