Anticancer agent 235

• Target :

  Reactive Oxygen Species|||Akt|||Apoptosis|||PI3K

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Metabolism|||Cytoskeletal Signaling|||Immunology/Inflammation|||Apoptosis|||NF-?B

• Bioactivity :

  Anticanceragent 235 (Compound 49) functions as a modulator of the PI3K/AKT/mTOR signaling pathway, enhancing reactive oxygen species (ROS) production and reducing mitochondrial membrane potential, thereby inhibiting the proliferation of cancer cell lines HCT116, Caco-2, AGS, and SMMC-772 with IC50 values ranging from 0.35 to 26.9 ?M. Additionally, it induces apoptosis and causes cell cycle arrest at the G2/M phase in HCT-116 cells.

• Smiles :

  ClC1=CC=C2C(=C1)C=C3C(=NC=4C=C(OC)C=CC43)N2C

• Molecular Formula :

  C17H13ClN2O

• Molecular Weight :

  296.75

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2411108-21-7