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Timcodar mesylate

CAT: 0931-T88332-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88332-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
183313-30-6
Target
Others, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Timcodar mesylate (VX-853-2) and its analog VX-710 function as inhibitors of mammalian multidrug-resistant bacterial efflux pumps, specifically blocking the efflux of ethidium bromide in Staphylococcus aureus. This capability suggests that Timcodar mesylate may boost the efficacy of antibiotics by impeding the bacterial efflux pumps, therefore lowering the minimum inhibitory concentrations of certain antibiotics against Gram-positive pathogens including Staphylococcus aureus, Enterococcus, and Streptococcus pneumoniae.
Smiles
CS(=O)(O)=O.ClC(C=C1)=CC=C1C[C@H](N(C)C(C(C2=CC(OC)=C(C(OC)=C2)OC)=O)=O)C(N(CC3=CC=CC=C3)C(CCC4=CC=NC=C4)CCC5=CC=NC=C5)=O.CS(=O)(O)=O
Molecular Formula
C45H53ClN4O12S2
Molecular Weight
941.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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