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Azalanstat mesylate

CAT: 0931-T70661-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70661-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
143484-80-4
Target
Others
Related Pathways
Others
Bioactivity
Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14?-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low density lipoprotein (LDL) cholesterol and apo B relative to high density lipoprotein (HDL) cholesterol and apo A-1.
Smiles
CS(O)(=O)=O.Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Molecular Formula
C23H28ClN3O5S2
Molecular Weight
526.063
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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