Azalanstat mesylate

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14?-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low density lipoprotein (LDL) cholesterol and apo B relative to high density lipoprotein (HDL) cholesterol and apo A-1.

• Smiles :

  CS(O)(=O)=O.Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1

• Molecular Formula :

  C23H28ClN3O5S2

• Molecular Weight :

  526.063

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  143484-80-4