Timcodar

• Description :

  Timcodar is a macrolide agent that can significantly inhibit fat accumulation during adipogenesis, with an effect similar to rapamycin. However, unlike rapamycin, Timcodar does not cause immunosuppression and glucose resistance. Timcodar can effectively inhibit adipogenesis transcriptional regulators PPAR and C/EBP, thereby inhibiting genes involved in fat accumulation.

• Product Name Alternative :

  VX-853

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/timcodar.html

• Smiles :

  O=C(N(CC1=CC=CC=C1)C(CCC2=CC=NC=C2)CCC3=CC=NC=C3)[C@H](CC4=CC=C(Cl)C=C4)N(C)C(C(C5=CC(OC)=C(OC)C(OC)=C5)=O)=O

• Molecular Formula :

  C43H45ClN4O6

• Molecular Weight :

  749.29

• References & Citations :

  [1]Timcodar (VX‐853) Is a Non‐FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [179033-51-3]