XRD-0394

CAT: 0931-T87647-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T87647-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2595308-10-2
Target
ATM/ATR|||DNA-PK
Related Pathways
DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Bioactivity
XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro [1].
Smiles
O=C1C2(C=3C=4C(N=CC3N1C)=CC(F)=C(C4)C=5C=C(NS(C)(=O)=O)C(OCCNC(C)C)=NC5)CCC2
Molecular Formula
C26H30FN5O4S
Molecular Weight
527.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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