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Tuspetinib hydrate

CAT: 0931-T87582-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87582-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2758339-04-5
Target
Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis
Bioactivity
Tuspetinib (HM43239) hydrate is a selectively active FLT3 inhibitor for oral administration, demonstrating IC50 values of 1.1 nM for FLT3 WT, 1.8 nM for FLT3 internal tandem duplication (ITD), and 1.0 nM for FLT3 D835Y kinases. As a reversible type I inhibitor, it suppresses FLT3 kinase activity and influences signaling pathways including p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Additionally, Tuspetinib hydrate inhibits leukemic cell proliferation and triggers apoptosis [1] [2] [3].
Smiles
ClC=1C(C=2C=3C(NC2)=CC(C)=CC3)=NC(NC4=CC(=CC(CN5C[C@@H](C)N[C@@H](C)C5)=C4)C6CC6)=NC1.O
Molecular Formula
C29H35ClN6O
Molecular Weight
519.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-145015ATuspetinib (hydrate)
GTR19235190-01Tuspetinib hydrate
HY-145015-01Tuspetinib
GTR19265190-01Tuspetinib dihydrochloride
HY-145015BTuspetinib (dihydrochloride)
A20826-25Tuspetinib (HM-43239) 25mg
A20826-50Tuspetinib (HM-43239) 50mg
A20826-100Tuspetinib (HM-43239) 100mg
A20826-10Tuspetinib (HM-43239) 10mg
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