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Tuspetinib

CAT: 0804-HY-145015-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145015-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3].
CAS Number
2294874-49-8
Product Name Alternative
HM43239
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tuspetinib.html
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=CN=C(NC2=CC(C3CC3)=CC(CN4C[C@H](N[C@H](C4)C)C)=C2)N=C1C5=CNC6=CC(C)=CC=C56
Molecular Formula
C29H33ClN6
Molecular Weight
501.07
Precautions
H302, H315, H319
References & Citations
[1]Miyoung Lee, et.al. Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia. Cancer Res July 1 2018 (78) (13 Supplement) 804.|[2]Naval G. Daver, et.al. HM43239, a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations: Phase 1 /2 Study. Blood 2019; 134 (Supplement_1) : 1331.|[3]JiSook Kim, et.al. Abstract 1293: HM43239, a novel FLT3 inhibitor in overcoming resistance for acute myeloid leukemia. Cancer Res July 1 2019 (79) (13 Supplement) 1293.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
T212318-01Tuspetinib dihydrochloride
T87582-01Tuspetinib hydrate
A20826-25Tuspetinib (HM-43239) 25mg
A20826-50Tuspetinib (HM-43239) 50mg
A20826-100Tuspetinib (HM-43239) 100mg
A20826-10Tuspetinib (HM-43239) 10mg
A20826-5Tuspetinib (HM-43239) 5mg
A20826-1Tuspetinib (HM-43239) 1mg
A20826-10mM-DTuspetinib (HM-43239) 10mM * 1mL in DMSO

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