EGFR/AURKB-IN-1

CAT: 0931-T86350-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T86350-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3008543-34-5

Target

EGFR, Aurora Kinase

Related Pathways

Angiogenesis, JAK/STAT signaling, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic

Bioactivity

EGFR/AURKB-IN-1 (compound 7) serves as a dual inhibitor targeting EGFR/AURKB, effectively inhibiting the phosphorylations of L858R EGFR and AURKB with IC50 values of 0.07 and 1.1, respectively. The compound engages with the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB. This binding action suppresses tumor cell growth, division, and metastasis, making it a valuable agent for cancer research [1].

Smiles

N(C1=C2C(NC(=C2)C=3N(C)N=CC3)=NC=N1)C4=CC=C(OCC5=CC=CC=C5)C=C4

Molecular Formula

C23H20N6O

Molecular Weight

396.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-157480-01	EGFR/AURKB-IN-1
BZ0199-3	PcDNA3.1-AURKB
Mab-607031	AURKB
sc-80543	EGFR (EGFR.1)
PVT39144	pExpress-1-Aurkb Plasmid
PPL00660-2b	PcDNA3.1-HA-AURKB
P30030	PExpress-1-Aurkb (rat)
307375-01	AURKB (HRP)
MBS850738-01	AURKB Antibody
P9191	POTB7-AURKB

EGFR/AURKB-IN-1

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