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ONO-AE3-208 sodium

CAT: 0931-T84444-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84444-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2309931-05-1
Target
Others, Prostaglandin Receptor
Related Pathways
Others, Immunology/Inflammation, GPCR/G Protein
Bioactivity
ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with 3% dextran sodium sulfate, results in severe colitis characterized by epithelial loss, crypt damage, and inflammation, thereby mimicking the effects of EP4 deletion. Further, this compound has been utilized to investigate the role of EP4 signaling in various biological contexts, including immune and autoimmune responses, inflammation, and cancer.
Smiles
C(C(NC1=C(CCCC(O)=O)C=CC(C#N)=C1)=O)(C)C=2C3=C(C(F)=CC2)C=CC=C3.[Na]
Molecular Formula
C24H20FN2O3?Na
Molecular Weight
426.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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208169GLAST (aa197-208) (SLC1A3, Solute carrier family 1 (glial high affinity glutamate transporter), member 3, EA6, EAAT1, FLJ25094, GLAST1, GLAST-1, OTTHUMP00000116002, Excitatory amino acid transporter 1, Sodium-dependent glutamate/aspartate transporter 1, Solute carrier family 1 member 3)

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