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5'-Ethynyl-2'-deoxycytidine

CAT: 0931-T84380-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84380-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
69075-47-4
Target
Others, HSV
Related Pathways
Others, Microbiology/Virology
Bioactivity
5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively) . Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.
Smiles
Nc1nc(=O)n(cc1C#C)[C@H]1C[C@H](O)[C@@H](CO)O1
Molecular Formula
C11H13N3O4
Molecular Weight
251.242
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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