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TM2 TEAD inhibitor

CAT: 0931-T83951-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83951-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1008768-41-9
Target
YAP
Related Pathways
Stem Cells
Purity
0.9991
Bioactivity
TM2 TEAD inhibitor is an effective and reversible inhibitor of TEA domain transcription factors, exhibiting IC50 values of 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively. TM2 TEAD inhibitor blocks TEAD-YAP binding and suppresses its transcriptional activity, exhibiting significant antiproliferative effects in YAP-dependent cancer cells. It demonstrates potent efficacy both as a monotherapy and in combination with MEK inhibitors. Furthermore, TM2 TEAD inhibitor strongly inhibits YAP-dependent liver organoid growth in vitro, supporting its potential application as an anticancer therapeutic strategy.
Smiles
O=C(NC=1C=CC=CC1)N2CCN(C(=O)C=3C=CC=C(OCCC4CCCCC4)C3)CC2
Molecular Formula
C26H33N3O3
Molecular Weight
435.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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