IDR 1002

CAT: 0931-T83942Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T83942Size:1 mg
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CAS Number
1224095-25-3
Target
Integrin
Related Pathways
Cytoskeletal Signaling
Bioactivity
IDR 1002, an innate defense regulator peptide, effectively diminishes bacterial load and mitigates inflammatory responses in murine models of sinusitis and acute bacterial lung infections. It suppresses LPS-induced activation of NF-?B and COX-2 while promoting the phosphorylation and activation of p38, ERK1/2, MSK1, and CREB.
Smiles
O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Molecular Formula
C79H130N26O13
Molecular Weight
1652.06
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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