AT-1001

• Target:

  AChR|||Others

• Related Pathways:

  Neuroscience|||Others

• Bioactivity:

  AT-1001 is an ?3?4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with ?3?4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal preparation, AT-1001 inhibits nicotine-induced [³H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII.

• Smiles:

  N([C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])C3=C(Br)C=CC=C3

• Molecular Formula:

  C15H21BrN2

• Molecular Weight:

  309.24

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1314801-63-2