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BRC4wt TFA

CAT: 0931-T83854-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83854-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide (Arg) 9, it effectively shortens DNA replication tract lengths and diminishes the frequency of homologous repair of camptothecin-induced DNA damage in vitro. Additionally, BRC4wt enhances the efficacy of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in inducing cell death in HeLa human cervical cancer and U2OS human osteosarcoma cells, albeit it does not affect non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells.
Smiles
NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC(CNC([C@H](CO)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CN=CN2)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C81H139N23O19.XCF3COOH
Molecular Weight
1739.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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