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HCAR2 agonist 1

CAT: 0931-T82233-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T82233-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1066676-21-8
Target
Others, HCAR
Related Pathways
GPCR/G Protein, Others
Bioactivity
HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1) . Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1].
Smiles
CC=1N2C(=C(C=N2)C3=CC=C(C(C)C)C=C3)N=CC1C(N[C@@H](COC4=CC=CC=C4)C)=O
Molecular Formula
C26H28N4O2
Molecular Weight
428.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C