ERBB agonist-1

• Target:

  Akt|||EGFR|||ERK

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Angiogenesis|||JAK/STAT signaling|||MAPK|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling

• Purity:

  0.999

• Bioactivity:

  ERBB agonist-1 (Compound EF-1) is an ERBB4 agonist (EC50=10.5 ?M) that induces ERBB4 receptor dimerization and phosphorylation of Akt and ERK1/2. It exhibits cardioprotective effects in mouse models and prevents myocardial fibrosis.

• Smiles:

  O=C1C=2C=CC=CC2N=C(SC(C(=O)NC3CC3)C=4C=CC=CC4)N1C5CCCC5

• Molecular Formula:

  C24H25N3O2S

• Molecular Weight:

  419.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  930856-19-2