Autophagy agonist-1

CAT: 0931-T205669-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205669-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

ATG, Autophagy, PTEN, CDK

Related Pathways

PI3K/Akt/mTOR signaling, Autophagy, Cell Cycle/Checkpoint

Bioactivity

Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.

Molecular Formula

C33H41N3O5

Molecular Weight

559.7

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-170992	Autophagy agonist-1
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GTR19262301-01	Autophagy/REV-ERB-IN-1
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PR27257-01	Beclin 1, Autophagy Related
MBS616231-01	Atg16L1 (Autophagy-related Protein 16-1, ATG16 Autophagy Related 16-like 1, APG16-like 1, APG16 Autophagy 16-like 1)
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Autophagy agonist-1

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