HTH-02-006

• Target:

  AMPK

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic

• Bioactivity:

  HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, and tumorigenesis. Additionally, it possesses an antifibrotic protective effect [1] [2].

• Smiles:

  IC1=CN=C(NC2=CC=C(N3CCN(C)CC3)C=C2OC)N=C1OC4=CC(NC(CC)=O)=CC=C4

• Molecular Formula:

  C25H29IN6O3

• Molecular Weight:

  588.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C