OKI-006

CAT: 0804-HY-144893Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144893Size:1 Each
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Description
OKI-006 is a potent and orally active inhibitor of histone deacetylase (HDAC) . OKI-006 is a unique congener of the natural product HDAC inhibitor largazole. Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. OKI-006 has the potential for the research of cancer disease[1].
CAS Number
[1315334-23-6]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oki-006.html
Solubility
10 mM in DMSO
Smiles
SCC/C=C/[C@@H]1CC(NCC2=NC(C(NC(C)(C(N[C@H](C(O1)=O)C(C)C)=O)C)=O)=CS2)=O
Molecular Formula
C21H30N4O5S2
Molecular Weight
482.62
References & Citations
[1]Diamond JR, et al. Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors. Mol Cancer Ther. 2022;21 (3) :397-406.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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